Brain-Derived Neurotrophic Factor and It’s Effect on Trigeminal Nerve Cells
Researchers at Oregon Health and Science University’s School of Dentistry have discovered when tissues are inflamed, the nerve cells carrying pain information from the head to the brain produce in large quantities a protein involved in pain signaling. This has implications for the treatments of such conditions as headaches, TMJ, toothache, and craniofacial pain, which is one of the most frequent pain conditions. The trigeminal nerve sends information about pain associated with headaches, head and neck cancer, TMJ, periodontal disease, trigeminal neuralgia, dental procedures, and more. Unfortunately the molecular mechanisms of trigeminal pain are not currently well understood and thought to involve inflammation. The researchers have found that the trigeminal nerve cells make a molecule called brain-derived neurotrophic factor (BDNF). This plays an important role in the development and normal functioning of the nervous system. In addition, stimulation of trigeminal … Read more