Month: July 2018

Having diabetes can lead to periodontitis

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Those with diabetes may end up with periodontitis, a gum infection which causes tooth loss. University of Pennsylvania researchers has found diabetes triggers changes in oral microbiome which increases inflammation and increases the risk of bone loss. Prior studies before this work did not show any evidence that diabetes affects the oral microbiome. In addition over four years ago, the European Federation of Periodontology and the American Academy of Periodontology issued a report describing how there is evidence that diabetes is linked to changes in the oral microbiome. The University of Pennsylvania researchers collaborated with Peking University, the University of São Paulo, Sichuan University, the Federal University of Minas Gerais, and the University of Capinas. The authors consulted with the Penn Center for Musculoskeletal Diseases. The researchers first explored the oral microbiome of diabetic mice compared to healthy mice. It was found … Read more

Microbes to Modify Nitrates in Migraine Headache Sufferers

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Researchers at the University of California San Diego have found that the mouths of those who suffer from migraine headaches have significantly more microbes with the ability to modify nitrates than people who do not have headaches. Many of the millions of Americans who suffer from migraines report an association between consuming foods with nitrates and the intensity of their headaches. The researchers were interested in exploring the idea that foods can trigger migraines and in particular exploring the microbiome connection with migraines. In addition, four in five cardiac patients who take nitrate-containing drugs often report headaches as a side effect. Nitrates are found in foods including processed meats and green leafy vegetables. Nitrite reducing bacteria found in the mouth can reduce the nitrates to nitrites. These nitrites can then be converted to nitric oxide when circulating in blood. Nitric oxide … Read more

Dental X-rays Show Vitamin D Deficiency

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McMaster anthropologists have found that human teeth hold important information about Vitamin D deficiency which can be identified by a dental X-ray. The researchers had previously discovered that human teeth hold a detailed and permanent record of Vitamin D deficiency. The teeth show microscopic deformities in dentin. This is preserved by enamel which protect teeth from breaking down. Vitamin D deficiency often occurs when a human does not get enough exposure to sunlight. This work is useful for examining the teeth of people who lived years ago to see if they were ever deprived of sunlight and had Vitamin D deficiency. An issue when looking for teeth deformities currently is that that a tooth must be cut open and there are limited teeth the researchers had access to. To avoid wasting specimens, the researchers tried to find a way to … Read more

How Does Cavity Causing Bacteria Survive?

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Researchers from the University of Basel’s Preventative Dentistry and Oral Microbiology Clinic and Department of Biomedical Engineering have found that extracellular polysaccharides play a central role in the survival capabilities of cavity causing bacteria in dental plaque. These bacteria live in biofilm and cause cavities by attacking dental enamel by converting sugar and starch into acids that dissolve out calcium from the enamel. The dissolution of calcium increases the concentration of calcium locally which creates an environment hostile to bacterial life. The researchers investigated how bacteria manage to survive in dental plaque despite conditions of hostility. They suggested that extracellular polysaccharides (EPS) support the bacteria’s survival capabilities. EPS are substances that build extracellular cariogenic bacteria from sugar residue. These substances create biofilm’s scaffolding and ensure bacteria are able to anchor themselves in  dental plaque. The researchers showed the more that calcium cariogenic … Read more