Author Archive | wisdom

Bacterium goes from the mouth to the heart to cause disease

The human mouth can have more than 700 different species of bacteria. Under normal circumstances these microbes co-exist as part of our resident oral microbiota but when they spread to other tissues via the blood stream, the results can be catastrophic. Researchers from the University of Bristol have revealed a potentially key molecular process that occurs in the case of infective endocarditis, a type of cardiovascular disease in which bacteria cause unwanted blood clots to form on heart valves. If untreated, this condition is fatal and even with treatment, mortality rates are high. There are over 2,000 cases of infective endocarditis in the United Kingdom (UK) annually and the amount is rising. The research involved the use of the UK national synchrotron facility, Diamond Light Source. Using this giant X-ray microscope the team was able to visualise the structure and dynamics of a protein called CshA which was believed to play an important role in targeting the oral bacterium Streptococcus gordonii to the tissues of the heart. The researchers were intrigued to find that CshA acts as a ‘molecular lasso’ to enable S. gordonii to bind to the surface of human cells. Such adhesive interactions are critical first steps in […]

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Tooth repair could occur using Alzheimer’s drug

The renewal of living stem cells in tooth pulp could occur using an Alzheimer’s drug has been discovered by a team of researchers at King’s College London. Following trauma or an infection, the inner, soft pulp of a tooth can become exposed and infected. In order to protect the tooth from infection, a thin band of dentine is naturally produced and seals the tooth pulp, but is insufficient to effectively repair large cavities. Currently dentists use human-made cements or fillings, such as calcium and silicon-based products, to treat these larger cavities and fill holes in teeth. This cement remains in the tooth and fails to disintegrate, meaning the normal mineral level of the tooth is never completely restored. In a paper published in Scientific Reports, scientists from King’s College London have proven a way to stimulate stem cells contained in the pulp of the tooth and generate new dentine in large cavities, potentially reducing the need for fillings or cements. The novel approach could see teeth use their natural ability to repair large cavities. When fillings fail or infection occurs, dentists have to remove and fill an area that is even larger than what is affected, and after multiple treatments the […]

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Tips to Afford Quality Dental Care

I was recently alerted to a post on thesimpledollar.com talking about how to afford quality dental care. The link for this post is at http://www.thesimpledollar.com/how-to-afford-quality-dental-care/. The article is written by Chris Sirico and was last updated on June 15, 2017. The article goes into some of the costs for common dental procedures and what you can do if you don’t have insurance. The article also goes into HSAs/FSAs, dental credit cards, dental financing, dental savings plans, dental insurance, and cosmetic dentistry. The article provides a very nice chart about the average cost for various dental procedures with and without insurance. For example the average cost of removing a single wisdom tooth is $416 without insurance and has an average cost of $250 to $750 if you have insurance. As another example the average cost of a surgical tooth extraction is $401 without insurance and has an average cost of $334 with insurance. The article says that if you don’t have dental insurance or have a limited budget then you can talk to the dental office staff to see if there is anything they can do to help. Dental financing or a dental savings plan may be able to help. With dental […]

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Method to Reduce Dental Implant Failure

Fifteen million Americans have crown or bridge replacements and three million have dental implants. Dental implants can be successful for many patients; however, five to 10 per cent of all dental implants fail. The reasons for this failure are mechanical problems, poor connection to the implanted bones, infection or rejection. When failure occurs the dental implant needs to be removed. The main reason for dental implant failure is periimplantitis. This destructive inflammatory process affects the soft and hard tissues surrounding dental implants. When pathogenic microbes in the mouth and oral cavity develop into biofilms, periimplantitis develop on dental implants. A research team from the School of Biological Sciences, Peninsula Schools of Medicine and Dentistry and the School of Engineering at the University of Plymouth, have joined forces to develop and evaluate the effectiveness of a new nanocoating for dental implants to reduce the risk of periimplantitis. The results are published in the journal Nanotoxicology. The research team created a new approach using a combination of silver, titanium oxide and hydroxyapatite nanocoatings. The combination to the surface of titanium alloy implants successfully inhibited bacterial growth and reduced the formation of bacterial biofilm on the surface of the implants by 97.5 per […]

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The Effect of a Single Dose of Antibiotics Prior to Wisdom Teeth Surgery

An interesting article titled “A Systematic Review on Effect of Single-Dose Preoperative Antibiotics at Surgical Osteotomy Extraction of Lower Third Molars” appears in the 2016 Journal of Oral and Maxilofacial Surgery and written by Karoline Brørup Marcussen and et. al. (vol. 74, pp. 693-703). The authors sought to conduct a systematic review of randomized controlled trials to evaluate the effectiveness of a single dose of preoperative antibiotics for preventing infection and alveolar osteitis [dry socket] in lower wisdom tooth surgery performed with osteotomy. Using antibiotic prophylaxis to reduce the incidence and severity of postoperative complications in surgical removal of impacted lower wisdom teeth is controversial. All randomized controlled trials  (RCTs) evaluating the effect of all types of prophylactic antibiotics administered 20 to 120 minutes preoperatively versus no antibiotics or placebo on the incidence of infection after surgical removal of lower impacted wisdom up to 1 week after surgery, were reviewed by the authors. In the search, 196 search hits were found. From these, 50 potentially relevant reports and 9 relevant reviews were identified. From these 7 RCTs were included and 3 additional were turned up in other searchers. Three RCTs reported infections, 4 RCTs reported alveolar osteitis, and 3 RCTs reported both infections and alveolar osteitis as outcomes. Finally a total of  1,390 patients from 10 RCTs were included. The meta-analysis showed that the use of antibiotics significantly reduced […]

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