Bone Loss from Valproate

The drug valproate is commonly used to treat epilepsy, bipolar disorder, and other conditions. However, valproate appears to reduce the formation of two key proteins important for bone strength. This comes a recent news as before the reason for bone less in patients taking valproate was a mystery. Glenn Morris and his fellow researchers have demonstrated that the use of valproate has grown over the years to include other diseases/disorders.  Valproate now is prescribed for mood disorders, migraine headache, and spinal muscular atrophy (SMA). Many SMA patients will develop weak bones as a result SMA which of course makes additional bone loss not welcome. Now the molecular explanation for the bone loss side effect of valproate is known. Valproate reduces production of collagen, the key protein that gives bone its strength, and does so by around 60%. The drug also … Read more

Hair Samples Prove Stress Causes Heart Attacks

New research has used male hair samples to prove that chronic stress and lead to cardiovascular disease such as a heart attack. It has been known for some time now that stress such as that from a marriage, job problems, and/or financial problems can lead to an increased risk of heart attack. However, there was never really a way to directly measure this stress. Drs. Gideon Koren and Stan Van Uum from the University of Western Ontario have developed a method to measure cortisol levels in hair which can provide a measure of stress levels before a problem like a heart attack occurs. It is well known that cortisol is a stress hormone and more of it is released when someone is stressed out. Dr. Koren explains  “We know that on average, hair grows one centimetre (cm) a month, and … Read more

Large Amounts of Fluoride Consumed by Young Children Leads to Fluorosis

A recent study looked at the role of fluoride in young children. It was found that young children who consume large amounts of fluoride through fluoridated water and beverages mixed with flouridated water as well as by swallowing toothpaste with fluoride have an increased chance of developing mild enamel fluorosis. The study noted that all of the fluorosis in the young children seen was mild and that they feel that the oral health of these young children was not adversely affected in anyway. If a child has mild enamel fluorosis there will be barely noticeable faint white lines or streaks on tooth enamel. The researchers used mothers of newborns from eight Iowa hospital postpartum wards between 1992 and 1995 which is known as the Iowa Fluoride Study. A total of 630 children were used in the study and questionnaires were … Read more

Fluoride in Water at Birth Helps Dental Health in Later Adult Life

A new study has looked at how fluoride in water that you drink when you are a child affects your teeth when you reach middle age. The study was done by Matthew Neidell and his colleagues and has found that the when you are a child and have added fluoride in your water it will help with dental health much later in adult life. “Your fluoridation exposure at birth is affecting your tooth loss in your 40s and 50s, regardless of what your fluoridation exposure was like when you were 20 and 30 years old,” said Neidell. Neidell and his researchers used data from the Centers for Disease Control and Prevention community health study in addition to a water census to look at the impact of drinking fluoridated water in the 1950s and 1960s on tooth loss in the 1990s. … Read more

Dentalhealth.org

I wanted to let everyone know about the site dentalheath.org. It is a site by the British Dental Health Foundation. There is a section for the public, a section for the press, and a section for professionals. Most people will find the Dental Health Information Leaflets section in the for the public part of the website to be useful. There are numerous useful dental related categories such as wisdom teeth, what to do following an extraction, x-rays, and so on. Since the site is from the British Dental Health Foundation, it’s intended audience is for people who live in Britain so this is important to keep in mind. Even so the information can be helpful for everyone. The site is arranged so that frequently asked questions for each category are asked and then answered. For example, in the wisdom teeth … Read more