Melatonin may be more effective than Amitriptyline for Migraine Prevention
Melatonin is an over the counter supplement and it has shown to be more effective than placebo for migraine prevention. In addition, it has a more favorable adverse effect profile than the tricyclic antidepressant amitriptyline. A study from a multicenter, randomized, double-blind, placebo-controlled trial showed that 3 mg of melatonin was more effective than placebo and had similar efficacy as 25 mg of amitriptyline. In addition, melatonin is better tolerated then amitriptyline without as much daytime sleepiness and no side effects of weight gain. Melatonin is a hormone that helps to regulate the sleep and wake cycle. It is often used to aid with sleep and help with jet lag. I have used melatonin (3mg or more most nights) to aid with falling asleep when it was suggested by a physician due to trouble falling asleep ever since having a … Read more