antibiotics

NIH awards grant to study responsible antibiotic use

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The National Institutes of Health (NIH) has awarded the University of Texas Health Science Center at San Antonio a four-year, $2.4 million grant to work with the American Dental Association Science & Research Institute (ADASRI) to perform a clinical trial study for the responsible use of antibiotics to treat periodontal disease also known as gum disease. The study will allow for the generatation of real-world data on periodontal disease treatments that are supplemented by antibiotics. The study will be lead by principle investigator Georgios Kotsakis, DDS, MS who is an associate professor of periodontics at the UT Health San Antonio School of Dentistry. More than 30 clinicians who belong to the National Dental Practice-Based Research Network (PBRN) will collect data for the study. The trial is expected to start in Spring 2023 and the periodontal patients will be treated and … Read more

Lemierre’s Syndrome after Wisdom Teeth Removal

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An interesting article titled “Lemierre’s Syndrome Following Extraction of Wisdom Teeth,” appears in the October 20, 2020 edition of the Cureus Journal of Medical Science (written by A. Keshary and M. Hagan, 12(10): e11061). The article describes a case of an 18 year old man who had his wisdom teeth extracted and then developed Lemierre’s Syndrome which rarely occurs after wisdom tooth removal but is is known to affect young and healthy adults; See Near Death Wisdom Teeth Removal Experience where another case has been discussed on this site in the past. Lemierre’s syndrome is a serious bloodstream infection typically caused by Fusobacterium necrophorum. It has a death rate of around 18% and thus if detected needs to be quickly treated with antibiotics. Very few cases of Lemierre’s syndrome after wisdom teeth surgery have occurred since antibiotics became readily available. In the … Read more

Wisdom Tooth Extraction Leads to Giant Lung Abscess

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A unique complication of wisdom teeth removal is described in the article titled “A 45-Year-Old Man With Acute Chest Pain, Fever, and Dyspnea After Tooth Extraction” appearing in the December 2021 edition of Chest written by Tashiro et al. (issue 160, no. 6, pp. e623 – e628). In the article, discussion is made of a healthy 45-year-old man who experienced respiratory failure due to a giant lung abscess that formed as a result of oral bacteria after a wisdom tooth extraction. Two days after having a wisdom tooth removed, the 45-year-old man in Japan developed chest pain on his right side. Two weeks after the wisdom tooth extraction, the man went to a hospital because he had a fever, difficulty breathing, and had a cough and purulent sputum. The man was in good health and visited a dentist twice a … Read more

Antibiotics for Dental Use Contributing to SuperBugs

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Research has shown that antibiotics prescribed by dentists for various dental surgeries and procedures may contribute to the development of Clostridium difficile (C. diff), a serious and potentially deadly infection with severe diarrhea. A common questions many patients ask if they are having their wisdom teeth out includes if they should take antibiotics. This topic has been covered before on teethremoval.com, for example see http://www.teethremoval.com/antibiotic_resistance.html, http://blog.teethremoval.com/patients-perception-of-antibiotic-need-after-teeth-removal/,and http://blog.teethremoval.com/the-effect-of-a-single-dose-of-antibiotics-prior-to-wisdom-teeth-surgery/. The current guidance seems to recommend a single dose of antibiotics prior to surgery for high risk patients for postoperative infections but other healthy patients do not need any antibiotics prior to surgery. During the annual ID Week2017, which is an annual meeting of the Infectious Diseases Society of America (IDSA), the Society for Healthcare Epidemiology of America (SHEA), the HIV Medicine Association (HIVMA) and the Pediatric Infectious Diseases Society (PIDS), researchers presented their findings on antibiotic prescriptions leading … Read more

The Effect of a Single Dose of Antibiotics Prior to Wisdom Teeth Surgery

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An interesting article titled “A Systematic Review on Effect of Single-Dose Preoperative Antibiotics at Surgical Osteotomy Extraction of Lower Third Molars” appears in the 2016 Journal of Oral and Maxilofacial Surgery and written by Karoline Brørup Marcussen and et. al. (vol. 74, pp. 693-703). The authors sought to conduct a systematic review of randomized controlled trials to evaluate the effectiveness of a single dose of preoperative antibiotics for preventing infection and alveolar osteitis [dry socket] in lower wisdom tooth surgery performed with osteotomy. Using antibiotic prophylaxis to reduce the incidence and severity of postoperative complications in surgical removal of impacted lower wisdom teeth is controversial. All randomized controlled trials  (RCTs) evaluating the effect of all types of prophylactic antibiotics administered 20 to 120 minutes preoperatively versus no antibiotics or placebo on the incidence of infection after surgical removal of lower impacted wisdom up to 1 week after surgery, were reviewed by the authors. In the search, 196 search hits were found. … Read more