Heart Infections on the Rise in Dental Patients After Antibiotic Reductions

In March 2008, the National Institute for Health and Care Excellence issued guidelines recommending that dentists should no longer give antibiotics before invasive treatments to people who are considered at risk of developing a life threatening heart infection. The life threatening heart infection is known as infective endocarditis and 40% of all cases are caused by bacteria in the mouth. Researchers at the University of Sheffield set out to explore the impact of these guidelines. It was found that an increase in cases of infective endocarditis was observed above what was expected. In March 2013, this increase accounted for an extra 35 cases of infective endocarditis per month. The researchers found that the number of  prescribed antibiotic prophylaxis fell by 89% from 10,900 prescriptions per month, before the 2008 NICE guidelines, to 1,235 a month by March 2008. The researchers … Read more

Bacteria and Fungus Can Team Up to Cause Cavities

An interesting article titled “Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes the virulence of plaque-biofilms in vivo,” appears in the February 2014, edition of Infection and Immunity, written by Megan L. Falsetta and et al. The article describes how although Streptococcus mutans is often cited as the main bacteria in dental caries (cavities), particularly in early-childhood caries (ECCs), it may not act alone and may team up with Candida albicans. The infection with both can double the number of caries and increase their severity as it did for rats in the study. Candida albicans adheres mainly to the cheek and tongue, while Streptococcus mutans sticks to the surfaces of teeth by converting sugars to a sticky glue-like material called extracellular polysaccharide (EPS). The researchers found that the exoenzyme that S. mutans uses to react with sugar to produce EPS also … Read more

Gum Disease Bacteria may Facilitate Rheumatoid Arthritis

As stated over on the risks of keeping wisdom teeth page, gum disease (periodontal disease) has been shown to have associations with many different systemic diseases. One such systemic disease is rheumatoid arthritis (RA). So far, any mechanism has remained elusive. In a recent study appearing in PLoS Pathogens, researchers at the University of Louisville School of Dentistry Oral Health and Systemic Diseases and other researchers from the European Union’s Gums and Joints project have uncovered how the bacteria responsible for periodontal disease known as Porphyromonas gingivalis effects rheumatoid arthritis. The researchers showed that this bacteria leads to faster progression, greater severity and earlier onset of RA and can cause bone and cartilage destruction. The researchers found the bacteria produces a unique enzyme, peptidylarginine deiminanse (PAD), which enhances collagen-induced arthritis (CIA), which is an arthritis produced in the lab designed … Read more

Removing Wisdom Teeth May Improve The Periodontal Health of Remaining Teeth

An interesting article titled “Removal of Symptomatic Third Molars May Improve Periodontal Status of Remaining Dentition,” by Carolyn Dicus-Brookes and et al. appears in the Journal of Oral and Maxillofacial Surgery (vol. 71, pp. 1639-1646, 2013). The article seeks to explore the impact of removing wisdom teeth on the periodontal status of adjacent second molars and other teeth located in the mouth specifically for patients who have mild symptoms of pericoronitis. As discussed recently over at Upcoming Changes to JOMS and AAOMS in 2014, select articles in JOMS will have press releases written by AAOMS staff to accompany them. This is one of those articles so that feature appears to have already been rolled out. To get an idea of what the press release entails I will briefly describe it. It is very short (less than 10 sentences) and fits … Read more

Gingivitis Bacteria Manipulate Your Immune System

An interesting article appears in the Journal of Leukocyte Biology discussing how the bacteria known for causing gum disease–Porphyromonas gingivalis–can manipulate the immune system to disable normal processes that would otherwise destroy it.The article talks about how this bacteria causes the anti-inflammatory molecule Interleukin-10 (IL-10) which inhibits the function of T-cells which would otherwise help to fight off the bacteria. The researchers discuss how it is important to understand how gingivitis bacteria affect the immune system since more than 50% of adults over 50 in the U.S. develop periodontal disease. The researchers used cells from mice that were exposed to Porphyromonas gingivalis and had some of them treated with an inhibiting antibody against IL-10 and the other portion of cells was not treated. The cells were then tested for interferon gamma production. The researchers found that an increase of interferon … Read more