Gingivitis Bacteria Manipulate Your Immune System
An interesting article appears in the Journal of Leukocyte Biology discussing how the bacteria known for causing gum disease–Porphyromonas gingivalis–can manipulate the immune system to disable normal processes that would otherwise destroy it.The article talks about how this bacteria causes the anti-inflammatory molecule Interleukin-10 (IL-10) which inhibits the function of T-cells which would otherwise help to fight off the bacteria. The researchers discuss how it is important to understand how gingivitis bacteria affect the immune system since more than 50% of adults over 50 in the U.S. develop periodontal disease. The researchers used cells from mice that were exposed to Porphyromonas gingivalis and had some of them treated with an inhibiting antibody against IL-10 and the other portion of cells was not treated. The cells were then tested for interferon gamma production. The researchers found that an increase of interferon … Read more