Inflammation Plays a Role in Alzheimer’s disease

Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn have shown that inflammatory mechanisms from the brain’s immune system drive the progression of Alzheimer’s disease. The research provides new insights into the pathogenetic mechanisms that may hold the potential for preventing Alzheimer’s disease before symptoms show up. Alzheimer’s disease is a neurodegenerative condition that eventually leads to dementia. The disease is associated with the aggregation of small proteins called “Amyloid-beta” (Abeta), known as “plaques,” that accumulate in the brain and are believed to harm neurons. Prior studies have shown deposits of Abeta trigger inflammatory mechanisms by the brain’s immune system. Researchers believe that deposition and spreading of Abeta likely precede any clinical symptoms by decades. Even so researchers do not fully understand the processes responsible and thus believe by doing so that effective treatments to target Alzheimer’s … Read more

Gum to Test for Inflammation in Mouth

Researchers from the University of Würzburg in Germany have developed a chewing gum that is capable of detecting inflammation in the mouth. The research was motivated by the fact that 6% to 15% of patients who receive dental implants develop an inflammatory response in in the years that follow. This is caused by bacteria destroying the soft tissue and the bone around the dental implant. The researchers provided proof of a principle by using studies of the saliva of patients at Merli Dental Clinic in Rimini. They showed that in the presence of inflammatory conditions, specific protein-degrading enzymes are activated in the mouth. These same enzymes break down a special ingredient of chewing gum within five minutes to release a bittering agent that could not be tasted before. In the future, patients will benefit from this method using a chewing gum diagnostic test … Read more

Having diabetes can lead to periodontitis

Those with diabetes may end up with periodontitis, a gum infection which causes tooth loss. University of Pennsylvania researchers has found diabetes triggers changes in oral microbiome which increases inflammation and increases the risk of bone loss. Prior studies before this work did not show any evidence that diabetes affects the oral microbiome. In addition over four years ago, the European Federation of Periodontology and the American Academy of Periodontology issued a report describing how there is evidence that diabetes is linked to changes in the oral microbiome. The University of Pennsylvania researchers collaborated with Peking University, the University of São Paulo, Sichuan University, the Federal University of Minas Gerais, and the University of Capinas. The authors consulted with the Penn Center for Musculoskeletal Diseases. The researchers first explored the oral microbiome of diabetic mice compared to healthy mice. It was found … Read more

Poor Oral Health is Linked to Depression: Implications for Public Health

A 2014 research project confirmed the link between poor oral health and depression, a relevant finding that can help in improving public health.  Oral health plays a significant role in the mental condition of a person, a two-way relationship that can become complex. On the one hand, dental care and treatments may produce anxieties and phobias. However, the absence of good oral hygiene can cause tooth problems, gum diseases, infections and other complications. Medications for mental health issues also produce side effects such as teeth grinding and dry mouths. The Importance of Oral Health and the Science Behind It Two National Health and Nutrition Examination Surveys (NHANES) examined the relationship of dental health and depression. Oral health questionnaires (OHQ) were used as bases for dental health while depression was measured using the Patient Health Questionnaire-9 (PHQ-9). Using logistic regression to measure the … Read more

Exploring Antibiotic Use with Lower Wisdom Teeth Surgery

An interesting article titled “Correlation of antibiotic prophylaxis and difficulty of extraction with post operative inflammatory complications in the lower third molar surgery” appears in the 2014 British Journal of Oral and Maxillofacial Surgery and written by J. Y. Lee and et al. (vol. 52, pp. 54-57). The article set out to investigate the correlation between antibiotic prophylaxis, difficulty of extraction, and postoperative complications of lower wisdom teeth. The authors say that indiscriminate antibiotic prophylaxis can lead to antimicrobial resistance and a shift in the microbial population. The authors performed a retrospective analysis of extraction of lower wisdom teeth performed at Korea University Guro Hospital over a two year time frame starting in January 2010. The authors only included cases in which cefditoren pivoxil was prescribed as an antibiotic. In addition, patients that were kept in a hospital due to postoperative complications were excluded from the … Read more