Tag Archives | inflammation

Long Term Consequences of Traumatic Brain Injury (TBI)

An interesting article appears in the journal PLOS ONE looking at the consequences of traumatic brain injury (TBI) using rate models. The researchers used rat models and found that overtime TBI results in progressive brain deterioration characterized by elevated inflammation and suppressed cell regeneration. Long-term neurological deficits from TBI related to inflammation may cause more severe secondary injuries and even predispose people to neurodegenerative diseases later in life. Traumatic brain injuries are important to study since troops in the U.S. military have increasingly suffered TBI from improvised explosive devices. One of the coauthors from the journal article (Dr. Paul R. Sanberg) says “Progressive injury to hippocampal, cortical and thalamic regions contributes to long-term cognitive damage post-TBI. Both military and civilian patients have shown functional and cognitive deficits resulting from TBI.” In the study researchers looked at different parts of the brain in the rat such as the hippocampus, corpus callosum white matter, thalamus, and dorsal striatum. The researchers found that neuroinflammation after TBI causes cell death that hinders the brain’s ability to regenerate. After looking at the rats brains eight weeks after trauma the researchers found “a significant up-regulation of activated microglia cells, not only in the area of direct […]

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Fish Oil to Help Periodontal Disease

I have previously discussed in this post http://blog.teethremoval.com/omega-3-fatty-acids-inversely-proportional-to-periodontitis/ that you should be taking omega 3 fatty acids such as fish oil regularly. This is because omega 3 fatty acids have been found to be inversely associated with periodontitis which is inflammation of the tissue surrounding the teeth. Recently researchers in Australia reviewed evidence from eight unique studies that involved humans to evaluate whether fish oil supplementation could be an adjunct therapy for periodontitis. Their review of these studies showed that improvements in clinical measures were common in all studies, but were scientifically significant in two that used a combination of fish oil and aspirin. Although not conclusive, intake of fish oil is recommended for health benefits which extend beyond just your teeth. Dr. Alison Coates from the University of South Australia says: “I would recommend that people ensure they have a sufficient intake of long chain omega-3 fatty acids in their diet for general health. In Australia, these types of fatty acids are considered to be essential with ~500 mg recommended as the suggested dietary target. This equates to approximately 2 fatty fish meals per week.” Dr. Coates and her colleagues say the the evidence for fish oil being effective in […]

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The Body Fights Gum Disease Better When You Are Not Fat

An interesting study was conducted by researchers at Case Western Reserve University School of Dental Medicine. The study included 31 obese people with gum disease. Half of those in the group with an average BMI of 39 had gastric bypass surgery and had had fat cells from the abdomen removed. This half did better than a control group of people with an average BMI of 35 who did not have gastric bypass surgery or had fat removed. It was stated that “All study participants underwent nonsurgical periodontal treatments of scaling/root planing and oral hygiene instructions for home care. While both groups showed improvement, the surgery group did even better on the measures for periodontal attachment, bleeding, probing depths and plaque levels.” Periodontal disease is a potential risk of keeping wisdom teeth and is discussed in more detail over at http://www.teethremoval.com/risks_of_keeping_wisdom_teeth.html. Periodontal disease has been found to be associated with numerous systemic diseases. The researchers in the study came up with 2 different hypotheses about why the surgery group did better than the control group. The first theory was that fat cells secrete more cytokines such as TNF and IL-6 which can cause insulin to be more resistant to properly function. Hence losing weight causes insulin to […]

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Periodontal disease may associate with breast cancer

An interesting study was published in Breast Cancer Res Treat (vol 127, pages 497 – 502, 2011) titled “Periodontal disease may associate with breast cancer,” by Birgitta Soder and et al. The study evaluated the association between periodontal disease and the incidence of breast cancer in a prospective study of 3273 randomly selected subjects aged 30 to 40 at baseline. The authors open by discussing how periodontal disease is characterized by chronic infection and inflammation leading to destruction of the bone surrounding the teeth. Some studies estimate that between 15 to 35% of the adult population in industrialized countries suffers from periodontal disease. Periodontal disease is initiated by a biofilm of bacteria on the teeth which triggers an immune-inflammatory response in the adjacent host tissues. Periodontal disease is of particular importance when considering whether or not to have wisdom teeth removed as it is a risk of developing when keeping them. This is discussed over at http://www.teethremoval.com/risks_of_keeping_wisdom_teeth.html.  Numerous studies and discussions have been made by the American Association of Oral & Maxillofacial Surgeons (AAOMS) as it relates to periodontal disease and third molars for example see their latest white paper on third molars (link and discussion at  http://blog.teethremoval.com/advocacy-white-paper-on-third-molar-surgery-by-aaoms/). The paper […]

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Bringing Teeth Back to Life

This post may sound a bit futuristic, but it is just one of the many ways nanotechnology can play a great role in impacting our lives. A study appearing in ACS Nano, describes a nano sized dental firm which could be used for bringing a diseased tooth back to life instead of leaving the tooth dead via a root canal. Nadia Benkirane-Jessel and colleagues state in the report that root canal procedures help prevent tooth loss in millions of people each year. During  a root canal a dentist removes the painful, inflamed pulp, the soft tissue inside the diseased or injured tooth that contains nerves and blood vessels. An area called regenerative endodontics in which the development and delivery of tissues to replace diseased or damaged dental pulp could become the future. The researchers have developed a multilayered, nano-sized film which contains a substance called alpha melanocyte stimulating hormone that could help regenerate dental pulp. The substance has anti-inflammatory properties and in the lab has been shown to fight  inflammation in dental pulp fibroblasts. This has the consequences of being able to  help revitalize damaged teeth and reduce the need for a root canal procedure which surely would please many. […]

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