inhibitor

Researchers at the University of Alabama at Birmingham have created a small molecule that prevents tooth cavities in a preclinical model. The inhibitor blocks the function of an enzyme in an oral bacterium and prevents it from forming biofilms. Specifically the inhibitor causes Streptococcus mutans (S. mutans) which is the prime bacterium that causes tooth decay and dental cavities, to not make the sticky bioflim that has it glue to a tooth surface. The selective inhibition of the sticky biofilm acts against S. mutans reduced dental caries in rats fed a diet intended to promote cavities. The glucan biofilm is made by three S. mutans glucosyltransferase (Gtf) enzymes. It is know what the crystal structure of the GtfC glucosyltransferase is, and the researchers used the structure to run numerous computer simulations for drug-like compounds for binding at the enzyme’s active site. Ninety compounds with diverse … Read more