Tag Archives | migraine

Migraine treament with monoclonal antibodies

Migraine headaches affect around 6 to 8% of males and 10 to 12% of females. It is one of the top five neurological conditions and costs people healthy lives. There is little research on how the current preventative treatments for migraine work. Researchers have speculated that the suppression of cortical spreading depression could be a process at play. Typically migraine patients are given beta-blockers such as propranolol and metroprolol, anticonvulsants valproate and topiramate, and the calcium channel bocker flunarizine as first line medications. These drugs have been shown in randomized placebo controlled studies to reduce the frequency of migraine attacks. A new treatment option could be placed in monoclonal antibodies that target a neuropeptide called CGRP (Calcitonin Gene-related Peptide). CGRP plays is thought to play a key role in headaches. CGRP receptor antagonists have been developed for the treatment of acute migraine and prevention. The medication has proved effected but in some cases treatment had to be abandoned due to acute side effects, including increases of liver enzymes. This has caused CGRP receptor antagonists to have not been approved to date. Newer studies show that the new monoclonal antibody against CGRP, or its receptor, appears to cause less side effects. As […]

Continue Reading 0

A new marker in blood for migraine?

An interesting article titled “Interictal, circulating sphingolipids in women with episodic migraine: A case-control study” written by B. L. Peterlin and et al. discusses that a new marker in blood may have been found for episodic migraine (Neurology, 2015). Episodic migraine is when a patient has less than 15 headaches per month. The researchers performed a study with 52 women with episodic migraine and 36 women who did not have any headaches. They all had to undergo a neurologic exam, gave blood samples, and had their body mass index measured. The women in the study with migraine had an average of 5.6 headache days per month. The blood samples were tested for a group of lipids that are known to help regulate inflammation in the brain and participate in energy homeostasis. The study found the total levels of lipids called ceramides were decreased in women with episodic migraine when compared to women with no migraines. It was found that women with migraine had approximately 6,000 nanograms per milliliter of total ceramides in their blood and women without headache had about 10,500 nanograms per milliliter. Each standard deviation increase in ceramide levels was found to be associated with over a 92% lower risk of having episodic migraine. The researchers […]

Continue Reading 0

Finding Relief From Headaches with Meditation

According to research published in the journal Headache, meditation may help migraine headache sufferers. Researchers have known that stress can be a trigger for headaches but there hasn’t been a whole lot of research done to evaluate meditation and it’s benefits. The researchers set out to develop a study to assess the feasibility, safety,and effects of a yoga and meditation intervention known as mindfulness-based stress reduction (MBSR) in adults who suffer from migraines. In the study 19 adults were randomly assigned to 2 groups with 10 of the adults receiving MBSR and 9 receiving standard medical care. The participants attended 8 weekly classes in order to learn MBSR techniques and were told to practice 45 minutes on their own 5 days per week. The participants in the study were evaluated before and after the trial period using measures such as mindfulness, self-efficacy, and disability. The patients maintained headache logs throughout the trial to document how often the headaches occurred, how long they occurred, and the intensity. The researchers found that MBSR study participants had fewer migraines and when migraines occurred they were less intense. In addition, patients with MBSR had headaches that were shorter and less disabling when compared to patients […]

Continue Reading 0

Reducing Migraines with Cosmetic Eyelid Surgery

An interesting article titled “Non-Endoscopic Deactivation of Nerve Triggers in Migraine Headache Patients,” appears in the 2014 issue of the journal Plastic and Reconstructive Surgery written by Lisa Gfrerer and et. al. The article describes a method to screen and select patients for a surgical migraine treatment technique used by plastic and reconstructive surgeons. The surgery decompresses nerves that trigger migraines. The surgery used is stated to be an alternative to an endoscopic approach used which works down from the scalp under the skin as the other approach is not always suitable. The surgery discussed involves incisions through the upper eyelid and the study demonstrated that this approach was equally as effective for the deactivation of nerves involved in migraine headaches. In the study migraine headaches were completely eliminated in roughly 51% of the patients while around 20% of the patients experiencing an 80% reduction in their migraine symptoms. Close to 33% of all patients had between 50% and 80% all of their migraine symptoms resolved. A total of 35 patients were included in this study and all suffered from chronic nerve compressed migraine headaches. In order to confirm that all the patients did in fact have chronic nerve compressed migraine […]

Continue Reading 0

Migraine attacks can increase after a stress let down

A new study published in Neurology discusses how migraine sufferers who experience reduced stress from one day to the next are at an increased risk on a migraine attack. Migraine is a chronic condition that affects millions of Americans. Numerous triggers are believed to contribute to a migraine attack. In the study the researchers at the Montefiore Headache Center and Einstein College of Medicine conducted a three month electronic daily diary study which recorded over 2,000 diary records and 110 migraine attacks in 17 participants.  The study compared levels of stress and reduction in stress as possible headache predictors. The study found an association between reduction in perceived stress and the occurrence of migraine headaches. The results were found to be strongest during the first six hours where decline in stress associated with a five fold increased risk of migraine attack. The hormone cortisol rises during times of stress and reduces pain which may contribute to the headache attack during relaxation. In the diary participants recorded information about their migraine attacks, stress ratings, hours of sleep, foods eaten, drinks and alcohol consumed, and information about their menstrual cycle. The study is important to migraine sufferers as stress is implicated here […]

Continue Reading 0

Powered by WordPress. Designed by Woo Themes