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The Effect of a Single Dose of Antibiotics Prior to Wisdom Teeth Surgery

An interesting article titled “A Systematic Review on Effect of Single-Dose Preoperative Antibiotics at Surgical Osteotomy Extraction of Lower Third Molars” appears in the 2016 Journal of Oral and Maxilofacial Surgery and written by Karoline Brørup Marcussen and et. al. (vol. 74, pp. 693-703). The authors sought to conduct a systematic review of randomized controlled trials to evaluate the effectiveness of a single dose of preoperative antibiotics for preventing infection and alveolar osteitis [dry socket] in lower wisdom tooth surgery performed with osteotomy. Using antibiotic prophylaxis to reduce the incidence and severity of postoperative complications in surgical removal of impacted lower wisdom teeth is controversial. All randomized controlled trials  (RCTs) evaluating the effect of all types of prophylactic antibiotics administered 20 to 120 minutes preoperatively versus no antibiotics or placebo on the incidence of infection after surgical removal of lower impacted wisdom up to 1 week after surgery, were reviewed by the authors. In the search, 196 search hits were found. From these, 50 potentially relevant reports and 9 relevant reviews were identified. From these 7 RCTs were included and 3 additional were turned up in other searchers. Three RCTs reported infections, 4 RCTs reported alveolar osteitis, and 3 RCTs reported both infections and alveolar osteitis as outcomes. Finally a total of  1,390 patients from 10 RCTs were included. The meta-analysis showed that the use of antibiotics significantly reduced […]

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