periodontal disease

Using Artificial Intelligence to Detect Gum Inflammation

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An interesting article titled “Accuracy of Artificial Intelligence-Based Photographic Detection of Gingivitis” appears in the International Dental Journal written by Reinhard Chun Wang Chau and et.al., 2023. The article used artificial intelligence (AI) to provide automated visual plaque control advice based on intraoral photographs. Periodontal disease is a chronic inflammatory disease that is categorised into gingivitis and periodontitis with reversible and irreversible tissue damages. It is beleived to affect mroe than 50% of the world. Periodontal disease is caused by accumulation of plaque biofilm along the gingival margin, which causes local gingival inflammation. As inflammation occurs at the gingival margin, redness, swelling, and loss of stippling appearance as loss of gingival fiber attachment are observed which are changes detected visually by dentists. The study used a deep learning algorithm named DeepLabv3+ built on Keras with TensorFlow to analyze intraoral photographs … Read more

Periodontal Disease associated with heart attacks

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In the past on this site links between periodontal disease and cardiovascular disease have been mentioned, see for example the posts Additional link between cardiovascular and periodontal disease and Periodontal Disease and Cardiovascular Risk. Periodontal disease is also known as gum disease. Recently, a study appearing in the Journal of the American Dental Association titled “Association between periodontal care and hospitalization with acute myocardial infarction” written by Romesh P. Nalliah and et. al. (April 19, 2022) has shown that those with periodontal disease are at increased risk of ending up in the hospital due to a heart attack. In the study researchers explored periodontal care and heart attack-related hospitalizations and aftercare by analyzing Iinsurance claims data from MarketScan Research Databases, which includes information from hundreds of millions of patients in the U.S. Patients were included if they had been hospitalized in … Read more

Periodontal Disease Bacteria Tied to Alzheimer’s Disease

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An interesting article titled “Alzheimer’s Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains” appears in the Journal of Alzheimer’s Disease written by Ursula Haditsch et al. (no. 75, pp. 1361–1376, 2020). The article seeks to explore the connections between Porphyromonas gingivalis (P. gingivalis), the main pathogen that causes chronic periodontitis, and Alzheimer’s disease (AD). In the article, the researchers sought to show that intraneuronal P. gingivalis and gingipain expression in vitro after infecting neurons derived from human induced pluripotent stem cells (iPSC). The researchers looked at the effect of the bacteria on the neurons at 24, 48, and 72 hours. The researchers used transmission electron microscopy, confocal microscopy, and bacterial colony to cause infection. They monitored gingipain expression by immunofluorescence and RT-qPCR, and protease activity with activity-based probes. The researchers used immunofluorescence, western blot, and ELISA to … Read more

Wisdom teeth and periodontal disease association in US adults

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An interesting article titled “Wisdom teeth, periodontal disease, and C-reactive protein in US adults” appears in Public Health written by Y. Zhang and et al. (vol. 187, pp. 97-102, 2020). The study sought to evaluate the associations among the presence of wisdom teeth, periodontal disease, and serum C-reactive protein (CRP) in the US adult population. Periodontal disease is a chronic gum disease which has been linked to many systemic diseases. An elevated level of CRP indicates systemic inflammation as it is a sensitive non-specific biomarker and has been linked to risk for cardiovascular disease. The end goal of the study was to generate population-based evidence to inform heart disease prevention and dental care. In the study the authors performed a secondary data analysis using the National Health and Nutrition Examination Survey (NHANES) 2009-2010 data from the national cross-sectional survey conducted … Read more

More Oral Pathogens and Less Bacterial Diversity in the Mouth Could Precede Stomach Cancer

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Researchers at the New York University College of Dentistry (NYU Dentistry) and New York University School of Medicine have found that elevated pathogen colonization and a lack of bacterial diversity in the mouth were identified in people with precancerous lesions that could precede stomach cancer. This work provides evidence that the increase in pathogens associated with periodontal disease (gum disease) could contribute to the development of precancerous lesions of stomach cancer. The specific finding of the study is that poor oral health is associated with an increased risk of precancerous lesions of stomach cancer. The potential of developing periodontal disease is one of the main risks of keeping wisdom teeth as discussed over at http://www.teethremoval.com/risks_of_keeping_wisdom_teeth.html. The American Cancer Society estimates that 26,370 new cases of stomach or gastric cancer were diagnosed in 2016, and this lead to 10,703 deaths.  Evidence suggests that chronic … Read more