Tag Archives | periodontal disease

Periodontal disease (gum disease) might increase the time it takes to become pregnant

Research presented at the the European Society of Human Reproduction and Embryology earlier this year showed that periodontal disease (gum disease) might increase the length of time it takes for a woman to become pregnant. Periodontal disease has been linked to many different types of systemic disease. Periodontal disease can lead to inflammation and bleeding around the gums which can lead to spaces called periodontal pockets. The research was led by Roger Hart who is a Professor of Reproductive Medicine and is also Medical Director of Fertility Specialists of the University of Western Australia. A total of 3737 pregnant women in the study were followed and outcomes of pregnancy were looked at for 3416 of the 3737 pregnant women. It was found that women who had periodontal disease (gum disease) took around 7 months to become pregnant while those women who did not have periodontal disease took roughly 5 months to become pregnant. Professor Hart said “Our data suggest that the presence of periodontal disease is a modifiable risk factor, which can increase a woman’s time to conception, particularly for non-Caucasians. It exerts a negative influence on fertility that is of the same order of magnitude as obesity.” The reason why […]

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Vitamin D Can Help Prevent Gum Infections

A study appearing in the June 2011 issue of Infection and Immunity titled “Vitamin D-Mediated Induction of Innate Immunity in Gingival Epithelial Cells.” written by Laura McMahon and et al. (vol. 79, no. 6, pages 2250-2256), suggests that making sure you have enough Vitamin D can help with the immune defense in the oral cavity. The authors found that an innate immune regulator TREM-1 can be induced by treating gingival cells with vitamin D. While still much work needs to be done looking at how exactly vitamin D can fight infections there is potential for targeted therapies in the future. The authors state “As vitamin D and calcium defciences can lead to increased inflammation, it is reasonable to hypothesize that there is an association with periodontal disease….vitamin D-mediated gene regulation of the innate immune response may be associated with the initial defense against colonization by periodontal pathogens.” For now all you can do is make sure you have enough Vitamin D in your diet and consider taking a supplement. Periodontal disease is explained further on the risks of keeping wisdom teeth page. Periodontal disease has been linked to systemic diseases and is often a reason why oral surgeons recommend having […]

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Gene Therapy for Gum Disease

Scientists at the University of Michigan have shown that gene therapy can be used to successfully stop the development of periodontal disease. The U-M group is the first known to use the gene delivery approach to show potential in treating chronic conditions such as periodontal disease, said William Giannobile, professor at the U-M School of Dentistry. “Gene therapy has not been used in non-life threatening disease. (Periodontal disease) is more disabling than life threatening,” said Giannobile, who also directs the Michigan Center for Oral Health Research and has an appointment in the U-M College of Engineering. “This is so important because the next wave of improving medical therapeutics goes beyond saving life, and moves forward to improving the quality of life.” The preclinical study offers was a collaboration with the Seattle-based biotechnology company Targeted Genetics. In July, Targeted Genetics released human trial results that showed the same gene therapy approach used to stop periodontal disease had positive affects in human patients with rheumatoid arthritis, another chronic, non-life threatening, disabling condition. The company tested 127 human subjects and showed a 30 percent improvement in such things such as pain relief and gain of function. People with rheumatoid arthritis are four times […]

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