Inflammation Plays a Role in Alzheimer’s disease

Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn have shown that inflammatory mechanisms from the brain’s immune system drive the progression of Alzheimer’s disease. The research provides new insights into the pathogenetic mechanisms that may hold the potential for preventing Alzheimer’s disease before symptoms show up. Alzheimer’s disease is a neurodegenerative condition that eventually leads to dementia. The disease is associated with the aggregation of small proteins called “Amyloid-beta” (Abeta), known as “plaques,” that accumulate in the brain and are believed to harm neurons. Prior studies have shown deposits of Abeta trigger inflammatory mechanisms by the brain’s immune system. Researchers believe that deposition and spreading of Abeta likely precede any clinical symptoms by decades. Even so researchers do not fully understand the processes responsible and thus believe by doing so that effective treatments to target Alzheimer’s … Read more