New Drugs to Help Prevent Migraine in Development

Earlier this year at the American Academy of Neurology’s 66th Annual Meeting in Philadelphia, two studies were presented which may be intriguing for those who suffer from migraine headaches. The studies explored the use of potential drugs to prevent migraine attacks from occurring. In both studies monoclonal antibodies were explored which target the calcitonin gene related peptide CGRP. Researchers have believed that CGRP is useful for migraine but drugs were never developed for it previously. One of the studies looked at 163 people who suffered from migraine between 5 and 14 days per month. These individuals received either a placebo or a IV dose of a drug ALD403. The individuals were followed for a period of 24 weeks. Those who received ALD403 had an average of 5.6 fewer migraine days per month compared to 4.6 fewer migraine days per month for … Read more

Can Making Less Money Lead to Migraines?

A study appearing by researchers in Neurology explores whether migraines limit the educational and career achievements of individuals which can lead to a lower income status. The study also explores whether problems related to low income such as stressful life events and poor access to health care increase the likelihood of developing migraines. The researchers used data from the American Migraine Prevalence and Prevention Study, a US national sample containing responses of 162,705 men and  women aged 12 and older who had some migraine symptoms able to be identified, their age, and household income. The authors defined low income as less than $22,500 per year for the household and high income as $60,000 per year or more. The researchers found the remission rate when migraines stop occurring for a time or for good was the same regardless of income. The researchers … Read more

Periodontal Disease and Pregnancy Risks

An often disagreed point in the literature is whether or not periodontal disease is associated with adverse pregnancy outcomes such as preterm births and low birth weight. I have discussed this some more on the risks of keeping wisdom teeth page over at I discussed how in a meta-analysis of 10 randomized trials in January 2011 found no evidence in favor of periodontal disease being associated with preterm births and low birth weight. The source for this study is Mariana Fampa Fogacci and et al. The Effect of Periodontal Therapy on Preterm Low Birth Weight: A Meta-Analysis. Obstetrics & Gynecology. vol. 117. issue 1. pages 153-165. January 2011. In a letter in J Can Dent Assoc 2012; 78: c120 there is an articled titled “Periodontal Disease and Pregnancy Risks,” which was published on on September 24, 2012 over at … Read more

Biostatistical Knowledge of Oral and Maxillofacial Surgery Residents

I found an interesting and critical study titled “Oral and Maxillofacial Surgery Residents Have Poor Understanding of Biostatistics,” by Al M. Best and Daniel M. Laskin appearing in the J Oral Maxillofac Surg vol. 71, pp. 227-234, 2013. The article discuss how the three main oral and maxillofacial surgery (OMS) journals have low quality evidence and how some of the articles can’t be taken at face value. Hence, the purpose of this study was to evaluate residents’ understanding of biostatistics and the interpretation of research results to see if the curricula of training programs should be changed to better prepare clinicians to practice evidence-based dentistry. In the study a 6 question survey was developed for OMS residents and compared to results for a similar survey of medical residents. Further, questions looking into demographic characteristics, the methodologic courses residents may have … Read more

Migraine in Children Can Lead to Reduced Performance in School

In an article titled “Migraine and migraine subtypes in preadolescent children Association with school performance,” appearing in Neurology in 2012 by Marco A. Arruda and Marcelo E. Bigal, a discussion is made that children with migraine may have below average school performance than kids who do not have headaches. The study looked at 5,671 children ages 5 to 12 from Brazil and found that those with migraine were 30% more likely to have below average school performance than those children with no headaches. The researchers collected information from the student’s teachers on their performance and also completed a questionnaire screening for emotional and behavioral problems. Further, the researchers interviewed parents of the students from medical history and other potential useful information. Of the 5,671 children around 0.6% had chronic migraine occurring 15 or more days per month and 9% had … Read more