Seventeen Year Old Teenager Due for Lung Transplant after Wisdom Teeth Removal

An unfortunate story appears in KRDO describing a seventeen year old man who had two impacted wisdom teeth extracted in October 2022 in Colorado. Seven days after the procedure the man started coughing up blood and ever since then his health has deteriorated. Prior to the surgery the teenager was in good health regularily lifting weights and playing with his siblings in his home state of Colorado. As reported in March 2023, now the man over four months later is an inpatient at a hospital and struggles to walk from a hospital bed to a bathroom that is five feet away. Two days after he started coughting up blood he went into septic shock where he was placed on a ventilator and moved into the intensive care unit of a hospital. His family is in a constant state of fear … Read more

Wisdom teeth could hold regenerative medicine answers

An interesting article titled “A single-cell atlas of human teeth” written by Pierfrancesco Pagella et al. appears in iScience (vol. 24, no. 102405, May 21, 2021). In the article the researchers analyzed five wisdom teeth that had been extracted to conduct a comprehensive single-cell atlas of the human tooth. The cells studied came from these five wisdom teeth and were extracted by dentists in Zurich. Isolating the cells from these wisdom teeth may have introduced variability between samples and some cells may not have survived the isolation process. Even so, the study found novel insights into how stem cells work which could help answer questions in regenerative medicine. In the study, the researchers at the University of Zurich and ETH Zurich used single-cell RNA sequencing to investigate cells present in dental pulp and the periodontium. The researchers compared patterns of … Read more

Nonsteroidal anti-inflammatory drugs better than opioids for pain after dental extractions

An interesting article titled “Acute Postoperative Pain Due to Dental Extraction in the Adult Population: A Systematic Review and Network Meta-analysis,” written by A. Miroshnychenko and et. al appears in the 2023 edition of the Journal of Dental Research. The article seeks to conduct a systematic review and meta-analysis to assess tto compare the effectiveness of 10 different pharmacological treatments including acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids, to the management of acute pain after dental tooth extractions. Further the article looked at the pain associated with pulpitis or its complications. The authors were motived to conduct the review based on the opioid crisis occuring in North America which has been discussed before on this site, see for example the posts Assessing the Impact of Three Day Opioids Limits for Dentists, Dentists Overprescribing Opioids to Adults in the U.S., and Reducing … Read more

Using an Eye Massager to Control Anxiety Before Wisdom Tooth Extraction

An interesting article titled “Massage Therapy to Control Anxiety Before Extraction of an Impacted Tooth,” appears in Cureus in October 4, 2022, written by Kunusoth R, Colvenkar S, Alwala A, et al. (vol. 14, no. 10, pp. 29893). The article discusses a simple technique to manage anxiety during dental visits using an eye massager. Many patients experience anxiety when seeing a dentist, see for example the posts Changes in Dental Anxiety over Time and Dental Anxiety and Fear: Impact on Oral Health. Dental anxiety can be caused by such things as a prior past negative dental experience, fear of needles, and a fear of gagging or choking. These patients are more likely to cancel their appointments and may be more difficult to treat. Various treatment options for dental anxiety exist such as described in the posts Do Wisdom Teeth Surgery … Read more

What is the norcebo effect and does it matter for dentistry?

An interesting article titled “What is the nocebo effect and does it apply to dentistry? A narrative review” written by T. Watanabe and et al. appears in the Journal of Oral Rehabilitation (2022). The article discusses the concept of a nocebo which is different than a placebo. A nocebo is where negative expectations lead to the effect of either clinical worsening, suboptimal treatment efficacy, or the occurrence of adverse events. A placebo on the other hand is where postive expectations leads to an effect that causes an improvement in symptoms. In the article the authors sought to explore the norcebo effect in dentistry which they say to date has been given very little attention which only a limited number of articles discussing it. The norcebo effect is real and has been demonstrated in numerous experimental and clinical settings, which hows … Read more