Sleep Chemicals Important for Brain Stimulation
The work shows that adenosine, a brain chemical most widely known as the cause of drowsiness, is central to the effect of deep brain stimulation, or DBS. The technique is used to treat people affected by Parkinson’s disease and who have severe tremor, and it’s also being tested in people who have severe depression or obsessive-compulsive disorder. Patients typically are equipped with a “brain pacemaker,” a small implanted device that delivers carefully choreographed electrical signals to a very precise point in the patient’s brain. The procedure disrupts abnormal nerve signals and alleviates symptoms, but doctors have long debated exactly how the procedure works. The new research, by a team of neuroscientists and neurosurgeons at the University of Rochester Medical Center, gives an unexpected nod to a role for adenosine and to cells called astrocytes that were long overlooked by neuroscientists. … Read more