Could a Medication One Day Be Given Instead of Braces to Control Tooth Movement?
Recent research from Tokyo Medical and Dental University (TMDU) showed that osteocytes have a crucial role in orthodontic tooth movement as the major source of receptor activator of nuclear factor kappa-Β ligand (RANKL) which is a protein critical to bone remodeling. It is known that the differentiation of osteoclasts is regulated by RANKL. However, the source of RANKL in the periodontal tissue during orthodontic tooth movement was not previously identified. Now thanks to the research team it is know that osteocytes mainly express RANKL and play a key role in the remodeling of bone surrounding teeth during orthodontic tooth movement. To explore this issue, the researchers used an orthodontic tooth movement model in which open coil springs were inserted between teeth of mice to move first molars. They then injected a neutralizing antibody against RANKL intended to reduce tooth movement. The … Read more