gum disease

New Antibiotic Shows Promise in Fighting Gum Disease and Potentially Other Serious Illnesses

by

A recent study published in the Journal of Oral Microbiology (Nik Yakar and et. al., Targeted elimination of Fusobacterium nucleatum alleviates periodontitis Volume 16, 2024 – Issue 1), suggests a potential breakthrough in the fight against periodontitis, a serious gum disease. Researchers found that a narrow-spectrum antibiotic, FP-100 (hygromycin A), effectively eliminates Fusobacterium nucleatum (F. nucleatum), a key bacterium linked to the onset and progression of periodontitis. F. nucleatum is a particularly concerning bacterium because it has been implicated in various systemic diseases beyond gum disease, including colorectal cancer and Alzheimer’s disease. How FP-100 Works: The study demonstrated that FP-100 specifically targets F. nucleatum without significantly disrupting the overall balance of the oral microbiome. This is crucial, as broad-spectrum antibiotics can often have detrimental effects on beneficial bacteria in the mouth and gut. In both in vitro and in vivo models, FP-100 effectively … Read more

Matcha from Green Tea Mouthwash Shows Promise in Fighting Gum Disease

by

Gum disease, also known as periodontitis, is an infection that damages the soft tissue and bone supporting teeth. Porphyromonas gingivalis (P. gingivalis )is one of the main culprits behind gum disease. If left untreated gum diesease can lead to tooth loss. The main cause of gum disease is poor oral hygiene, which allows plaque and bacteria to build up on teeth and under the gumline. Brushing teeth twice a day, flossing daily, and visiting the dentist regularly for cleanings all help to prevent gum disease. If you’re experiencing gum inflammation or discomfort, a simple saltwater rinse can offer relief. Mixing a half-teaspoon of table salt into warm water creates a soothing solution. Swishing with this rinse can help reduce inflammation and ease any pain you might be experiencing. Smoking and excessive alcohol consumption are known culprits in worsening gum disease. … Read more

Association between brain and periodontitis

by

An interesting article titled Periodontitis causally affects the brain cortical structure: A Mendelian randomization study written by Mengqiao Wang and et. al. appears in the Journal of Periodontal Research, published December 7, 2023. The authors sought out to estimate whether genetically proxied periodontitis impacts the brain cortical structure. The lines between oral and neurological health blur further, as the article reveals that gum disease isn’t just a dental concern, but can potentially impact the way our brains are wired. The researchers found a causal link between periodontitis, also known as gum disease, and changes in the structure of the brain’s cortex. This is the first study to show such a connection, and may open a new avenue for understanding neurological diseases. To uncover a potential cause-and-effect link between gum disease and brain structure, researchers employed a clever technique called “Mendelian randomization.” … Read more

Tooth loss associated with brain shrinkage

by

An interesting article titled “Associations of Dental Health With the Progression of Hippocampal Atrophy in Community-Dwelling Individuals: The Ohasama Study,” written by Satoshi Yamaguchi and et. al. appears in Neurology, published on Juy 5, 2023. The article sought to explore associations between the number of teeth present and hippocampal atrophy older patients 55 years and older in a longitudinal study. The hippocampus is part of the brain that is important for learning and memory. With Alzheimer’s disease, atrophy of the hippocampus is a common feature but other factors, such as periodontitis (gum disease) can be seen. The researchers were under the assumption that the association between dental health and hippocampal atrophy might be due to inflammation. Gum disease is a chronic inflammatory condition, and inflammation has been shown to damage the hippocampus. The study included 172 people with an average … Read more

Oral Bacteria May Lead to More Heart Disease

by

An interesting article titled “Associations of genetic and infectious risk factors with coronary heart disease” appears in eLife published on February 14, 2023, written by Flavia Hodel and et. al. The article discusses how common bacteria that has been linked with periodontal disease, oral cancers, and bad breath increase the chance of developing heart disease. In the past it has been discussed on this site how Brushing Teeth Twice a Day to Help Prevent Heart Disease and Bacterium goes from the mouth to the heart to cause disease. In the current article, the authors mention how cardiovascular diseases (CVDs) are the leading cause of mortality in the world and it is believed 17.9 million people die from CVD each year. The authors performed multiplex serological testing for persistent or frequently recurring infections and genome-wide analysis in a prospective population study. … Read more