gum disease

Oral Bacteria May Lead to More Heart Disease

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An interesting article titled “Associations of genetic and infectious risk factors with coronary heart disease” appears in eLife published on February 14, 2023, written by Flavia Hodel and et. al. The article discusses how common bacteria that has been linked with periodontal disease, oral cancers, and bad breath increase the chance of developing heart disease. In the past it has been discussed on this site how Brushing Teeth Twice a Day to Help Prevent Heart Disease and Bacterium goes from the mouth to the heart to cause disease. In the current article, the authors mention how cardiovascular diseases (CVDs) are the leading cause of mortality in the world and it is believed 17.9 million people die from CVD each year. The authors performed multiplex serological testing for persistent or frequently recurring infections and genome-wide analysis in a prospective population study. … Read more

Periodontitis has a relationship to atrial fibrosis in atrial fibrillation

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An interesting article titled “Relationship Between Periodontitis and Atrial Fibrosis in Atrial Fibrillation: Histological Evaluation of Left Atrial Appendages” appears in the JACC: Clinical Electrophysiology written by Shunsuke Miyauchi and et. al. (Volume 9, Issue 1, January 2023, Pages 43-53). The article seeks to explore the relationship of periodontitis with atrial fibrillation (AF) and atrial fibrosis. Periodontitis (periodontal disease) is an inflammatory disease where bacteria accumulates at the gum line. The likelyhood of periodontal disease occurring later in life in the wisdom tooth region is a reason dentists and oral surgeons give to support removing healthy wisdom teeth in the teenage and twenty years of age. Various associations to periodontitis has been showed over the years as covered before on this site see for example the posts Omega 3 Fatty Acids Inversely Proportional to Periodontitis, Blueberry extract could help treat periodontitis, Estrogen … Read more

Physical activity can help reduce gum disease

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An interesting article titled “Leisure-Time and Occupational Physical Activity Demonstrate Divergent Associations with Periodontitis: A Population-Based Study,” appears in the January 2, 2023, edition of Journal of Clinical Periodontology written by Marruganti Crystal et al. The article discusses how physical activity can help to reduce inflammation, which can potentially decrease the risk of developing periodontitis also known as gum disease. Reducing gum disease has been discussed before on this site, see for example the posts Blueberry extract could help treat periodontitis and Natural Supplements to Improve your Periodontal Health. In the article the authors examine data from the U.S. National Health and Nutrition Examination Survey (NHANES) 2009-2014 database. They retrieved data from 10,679 adults and assessed physical activity from the Global Physical Activity questionnaire which classified activity as either high or low leisure-time or occupational activity. A full-mouth periodontal examination was … Read more

Using Artificial Intelligence to Detect Gum Inflammation

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An interesting article titled “Accuracy of Artificial Intelligence-Based Photographic Detection of Gingivitis” appears in the International Dental Journal written by Reinhard Chun Wang Chau and et.al., 2023. The article used artificial intelligence (AI) to provide automated visual plaque control advice based on intraoral photographs. Periodontal disease is a chronic inflammatory disease that is categorised into gingivitis and periodontitis with reversible and irreversible tissue damages. It is beleived to affect mroe than 50% of the world. Periodontal disease is caused by accumulation of plaque biofilm along the gingival margin, which causes local gingival inflammation. As inflammation occurs at the gingival margin, redness, swelling, and loss of stippling appearance as loss of gingival fiber attachment are observed which are changes detected visually by dentists. The study used a deep learning algorithm named DeepLabv3+ built on Keras with TensorFlow to analyze intraoral photographs … Read more

Periodontal Disease Bacteria Tied to Alzheimer’s Disease

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An interesting article titled “Alzheimer’s Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains” appears in the Journal of Alzheimer’s Disease written by Ursula Haditsch et al. (no. 75, pp. 1361–1376, 2020). The article seeks to explore the connections between Porphyromonas gingivalis (P. gingivalis), the main pathogen that causes chronic periodontitis, and Alzheimer’s disease (AD). In the article, the researchers sought to show that intraneuronal P. gingivalis and gingipain expression in vitro after infecting neurons derived from human induced pluripotent stem cells (iPSC). The researchers looked at the effect of the bacteria on the neurons at 24, 48, and 72 hours. The researchers used transmission electron microscopy, confocal microscopy, and bacterial colony to cause infection. They monitored gingipain expression by immunofluorescence and RT-qPCR, and protease activity with activity-based probes. The researchers used immunofluorescence, western blot, and ELISA to … Read more