heart health

An interesting article titled “Porphyromonas gingivalis, a periodontal pathogen, impairs post-infarcted myocardium by inhibiting autophagosome–lysosome fusion” written by Yuka Shiheido-Watanabe and et. al. appears in the International Journal of Oral Science. This study investigated the molecular mechanisms underlying the adverse effects of P.g. infection on post-MI myocardial remodeling. P.g. infection impaired autophagosome–lysosome fusion, a step in the autophagy process. The study showed that the periodontal pathogen Porphyromonas gingivalis can exacerbate heart damage after a heart attack. The researchers found that the bacterium can accumulate at the site of injury and contribute to tissue damage. The mechanisms for which this occurs is stil under investigation. In an effort to understand how Porphyromonas gingivalis contributes to heart damage, the researchers developed a modified version of the bacterium that lacks a key protein called gingipain. This protein is known to protect cells from … Read more