hospitals

The Immune System in Critically Ill Children with Influenza

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An interesting article discussed the results of a study looking at the immune system in critically ill children. The article describes a study published in early 2013 in the January issue of Critical Care Medicine. Recent evidence indicates that the suppression of innate immune system function can occur in critically ill patients. In this study patients with innate immune suppression produced reduced amounts of tumor necrosis factor (TNF)-α  when their blood is stimulated with lipopolysaccharide (LPS). The article states “Results indicated that despite high levels of circulating pro-inflammatory cytokines, critically ill children with influenza demonstrated lower TNFα production capacity compared with healthy control subjects. Further, children who died from influenza had markedly lower TNFα production capacity compared with survivors.” Hence this study suggests that the reduction of immune function in these children who are critically ill may make them more prone … Read more

Patient Harm in Medical Care

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The New England Journal of Medicine has recently published an article titled “Temporal Trends in Rates of Patient Harm Resulting from Medical Care.” This article was conducted by Christopher Landrigan and 5 other researches, appeared in the November 25, 2010, edition and you can download and view it at http://www.nejm.org/doi/pdf/10.1056/NEJMsa1004404 The article explores a random sample of 10 hospitals located in the state of North Carolina in the U.S.  A total of 2,341 patients were looked at from this sample and 588 of them had what was identified as a harm meaning that the patient was somehow harmed as a result of medical procedures, medications, or something else that was performed or given during their care. “Of 588 harms that were identified, 245 (41.7%) were temporary harms requiring intervention…  251 (42.7%) were temporary harms requiring initial or prolonged hospitalization. An … Read more