migraine

Migraine Associated with Changes in Structure of Arteries

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A recent study by researchers from the Perelman School of Medicine at the University of Pennsylvania has shown the arteries supplying blood flow to the brain is more likely to be incomplete in people who experience migraine. The arterial supply of blood to the brain is protected by numerous connections between the major arteries which is known as the circle of Willis. Those who experience migraine and especially migraine with aura are more likely than those without migraine to be missing some components of the circle of Willis. These structural changes in the circle of Willis are something people are born with. In this study, which appeared in PLOS ONE, the researchers suggest that these structural alterations of the blood supply to the brain may increase susceptibility to changes in cerebral blood flow, which may contribute to abnormal neuronal activity … Read more

Migraine May Alter Brain Structure Permanently

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An article appearing in Neurology, explores the effects of a migraine on the brain’s structure on a long term basis. The study suggests that migraine may permanently alter brain structure which is counter to previously held beliefs that migraine has no long term consequence for the brain.  For example, see the post titled Are Migraine Related Changes Related to Impaired Cognition? where a study concluded that women with migraine have no long term effects of cognition over time. See also the post Do Migraines Lead to Cognitive Decline? In the current study, researchers explored 6 population based studies and 13 clinic based studies to determine if people who have migraine had an increased risk of brain lesions, brain volume changes, or other abnormalities as measured from an MRI of the brain. The researchers found that migraine with aura increased the … Read more

The Social Stigma of Migraine Headaches

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An interesting study has been conducted by researchers at Thomas Jefferson University looking at the social stigma of migraine headaches. The study appears in PLOS ONE, January 16, 2013. The study was led by William B. Young a neurologist and he is quoted at saying “When people treat my patients as if they are to blame because they have a severe, debilitating disease, they are contributing to the problem and making life harder for them.” The researchers find that high levels of social stigma for migraine suffers is due to the impact of a chronic migraine of their work lives. Dr. Young says “I don’t think people realize that it is not unusual for people with migraine to have severe headaches every day—to be so disabled that they are unable to work. This is what causes the stigma—the fact that … Read more

Electric Stimulation of Brain Releases Powerful Painkiller

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Researchers have been exploring delivering electricity through sensors on the skulls of chronic migraine patients and have found a decrease in the intensity of pain of their headaches. A recent study published in Frontiers in Psychiatry has shown that when electricity is sent to certain regions in the brain of a patient with chronic, severe facial pain it releases an opiate-like substance and powerful painkiller. In the study, researchers administered a radiotracer that reached important brain areas in a patient with trigeminal neuropathic pain. They then applied electrodes and electrically stimulated the skull right above the motor cortex  for 20 minutes during a PET scan which is known as transcranial direct current stimulation (tDCS). The radiotracer was designed to measure the local brain release of mu-opioid, a natural substance that alters pain perception. The researchers argue that this is the … Read more

Melatonin may be more effective than Amitriptyline for Migraine Prevention

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Melatonin is an over the counter supplement and it has shown to be more effective than placebo for migraine prevention. In addition, it has a more favorable adverse effect profile than the tricyclic antidepressant amitriptyline. A study from a multicenter, randomized, double-blind, placebo-controlled trial showed that 3 mg of melatonin was more effective than placebo and had similar efficacy as 25 mg of amitriptyline. In addition, melatonin is better tolerated then amitriptyline without as much daytime sleepiness and no side effects of weight gain. Melatonin is a hormone that helps to regulate the sleep and wake cycle. It is often used to aid with sleep and help with jet lag. I have used melatonin (3mg or more most nights) to aid with falling asleep when it was suggested by a physician due to trouble falling asleep ever since having a … Read more