oral cancer

Micro RNA and it’s role in Oral Cancer Detection

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New research has emerged in Clinical Cancer Research which could aid in the diagnosis of oral cancer by looking at saliva, specifically MicroRNAs. MicroRNAs are molecules produced in cells that have the ability to simultaneously control activity and assess the behavior of multiple genes. Knowing the that microRNA is present in saliva represents a major step for the detection of oral cancer at an early stage. “It is a Holy Grail of cancer detection to be able to measure the presence of a cancer without a biopsy, so it is very appealing to think that we could detect a cancer-specific marker in a patient’s saliva,” said Jennifer Grandis, M.D. David T. Wong, D.M.D., D.M.Sc. and his colleagues measured microRNA levels in the saliva of 50 patients with oral squamous cell carcinoma and also in 50 healthy control patients. They were … Read more

Oral Cancer Diagnosed Too Late

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Across the world, more than 500,000 new cases of cancer of the mouth are diagnosed each year. The majority are found too late, causing many people to die within five years. There is little information related to early diagnosis and referral. Although the need for prosthodontics was expected to decline with the promotion of preventive measures, it is actually increasing with the aging population. The highest risk of developing oral cancer is in adults over 40 who use both tobacco and alcohol. The majority of oral, head and neck cancer are initially diagnosed in a late stage, which has a five year prognosis of less than 50 percent. If these tumors are found in their earliest stage, the five year prognosis becomes a very good 95 percent. All dentists are  trained to detect these tumors in an early stage. Even … Read more