periodontitis

Gum diease can lead to selective disarming of the immune system

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A new study has shown that bacteria responsible for many cases of periodontitis causes dysbiosis in a two prong manipulation of the immune system. The researchers say that periodontal bacterium porphyromonas gingivalis acts on two molecular pathways to block immune cells’ killing ability while preserving the cells’ ability to cause inflammation. This protects these bacteria from being removed by the immune system and leads to bone loss and inflammation which is characteristic of periodontitis. The researchers say when inflammation occurs breakdown products are produced which causes dysbiosis and creates a vicious cycle. P. gingivalis is known as a keystone pathogen. Their presence may be relatively few in the mouth but they can exert a large pull on the overall microbial ecosystem. P. gingivalis doesn’t actually cause periodontitis but is responsible for causing the process that leads to it. The researchers believe that … Read more

High-Level Evidence to Identify Diseases and Disorders Associated with Periodontal Disease

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An interesting article appears in J Can Dent Assoc, 2012, 78:c25, titled ” Separating Fact from Fiction: Use of High-Level Evidence from Research Syntheses to Identify Diseases and Disorders Associated with Periodontal Disease,” by Amir Azarpazhooh and Howard C. Tenenbaum. The article describes how it is known that periodontitis has been correlated with several diseases and attempts to look at the more robust associations. In the risks of keeping wisdom teeth page http://www.teethremoval.com/risks_of_keeping_wisdom_teeth.html this has been mentioned and several studies are cited. This page states “These potential systemic diseases that may be associated with periodontal disease include premature delivery of low-birth weight infants, coronary artery disease, coronary heart disease, renal vascular disease, stroke, diabetes, bacterial pneumonia, chronic obstructive lung disease, and Alzheimer’s disease.” The article discussed above uses meta-analyses and systematic reviews available up to June 2011. This article states “This high-level evidence … Read more

Oral Bacteria That Causes Periodontitis Delievers a One-Two Punch

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Oral health care workers and scientists have know for many years that bacteria cause periodontitis (gum disease); however, they were not sure exactly what bacteria was response. Recently the bacteria that causes periodontitis (gum disease) has been identified by a University of Michigan study. This bacterium is known as NI1060. It was also found that this triggers a normally protetive protein in the oral cavity called Nod1 to trigger bone destroying cells. In normal circumstances Nod1 fights harmful bacterium in the body. Hence, it was that the bacteria that causes gum disease triggers a one-two punch by also causing normally protective proteins to then destroy more bone. In normal cases No1 helps to fight infection by recruiting neutrophils which are blood cells that act as bacterial killers. Nod1 also removes harmful bacteria during infection. When periodontitis (gum disease) occurs NI1060 … Read more

Gum Disease More Common With Old Age

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A recent study which appeared in Nature Immunology shows that the deterioration in gum health which occurs with increasing age is associated with a drop in the level of a chemical called Del-1. Periodontitis is a disease of the gums which causes bleeding and bone loss which can, over time, lead to loss of teeth. Periodontitis  is caused by an over-active immune response to bacteria that grow in the mouth. As people age they are more likely to suffer from inflammatory diseases, including gum disease. The new research investigated gum disease in young and old mice and found that an increase in gum disease in the older animals was accompanied by a drop in the level of Del-1. Del-1 is known to restrain the immune system by stopping white blood cells from sticking to and attacking mouth tissue. In mice that had … Read more

Fish Oil to Help Periodontal Disease

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I have previously discussed in this post https://blog.teethremoval.com/omega-3-fatty-acids-inversely-proportional-to-periodontitis/ that you should be taking omega 3 fatty acids such as fish oil regularly. This is because omega 3 fatty acids have been found to be inversely associated with periodontitis which is inflammation of the tissue surrounding the teeth. Recently researchers in Australia reviewed evidence from eight unique studies that involved humans to evaluate whether fish oil supplementation could be an adjunct therapy for periodontitis. Their review of these studies showed that improvements in clinical measures were common in all studies, but were scientifically significant in two that used a combination of fish oil and aspirin. Although not conclusive, intake of fish oil is recommended for health benefits which extend beyond just your teeth. Dr. Alison Coates from the University of South Australia says: “I would recommend that people ensure they have a … Read more