placebo

What is the norcebo effect and does it matter for dentistry?

by

An interesting article titled “What is the nocebo effect and does it apply to dentistry? A narrative review” written by T. Watanabe and et al. appears in the Journal of Oral Rehabilitation (2022). The article discusses the concept of a nocebo which is different than a placebo. A nocebo is where negative expectations lead to the effect of either clinical worsening, suboptimal treatment efficacy, or the occurrence of adverse events. A placebo on the other hand is where postive expectations leads to an effect that causes an improvement in symptoms. In the article the authors sought to explore the norcebo effect in dentistry which they say to date has been given very little attention which only a limited number of articles discussing it. The norcebo effect is real and has been demonstrated in numerous experimental and clinical settings, which hows … Read more

Placebo Pain Control

by

New research has come to light to show the “placebo effect” involves evolutionarily old pain control pathways in the human brainstem. Placebo analgesia refers to a person’s relief from pain following being given a chemically inert substance. It is thought to be due to a person’s belief that a potent pain medication was administered. Endogenous opioids are naturally produced by the brain in small amounts and play a key role in the relief of pain and anxiety. Brain imaging studies have shown placebo analgesia stimulates release of endogenous opioids from higher brain regions. “It has been hypothesized that placebo analgesia also recruits the opioidergic descending pain control system, which inhibits pain processing in the spinal cord and, therefore, subsequently reduces pain-related responses in the brain, leading to a decreased pain experience,” says Falk Eippert. Eippert and his colleagues used advanced … Read more