regenerative medicine

New Approach to help Bones Heal

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An interesting article titled “Expansion of the sagittal suture induces proliferation of skeletal stem cells and sustains endogenous calvarial bone regeneration” written by Zahra A. Aldawood and et. al. appears in Proceedings of the National Academy of Sciences (vol. 120, no. 16, 2023). The article explores a new method to promote bone regeneration in mice. The researchers discuss how in newborn humans and mice and thse up to arond 2 years of age, calvarial bone defects, on the skullcap, can naturally regenerate. This abiliy to naturally heal damage to the bones that form the top of the skull, is lost in adults. The calvarial sutures are reservoirs of calvarial skeletal stem cells (cSSCs), which are cells responsible for calvarial bone regeneration. The authors believed the regenerative potential of the newborn calvaria is from the presence of a large number of cSSCs … Read more

Wisdom teeth could hold regenerative medicine answers

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An interesting article titled “A single-cell atlas of human teeth” written by Pierfrancesco Pagella et al. appears in iScience (vol. 24, no. 102405, May 21, 2021). In the article the researchers analyzed five wisdom teeth that had been extracted to conduct a comprehensive single-cell atlas of the human tooth. The cells studied came from these five wisdom teeth and were extracted by dentists in Zurich. Isolating the cells from these wisdom teeth may have introduced variability between samples and some cells may not have survived the isolation process. Even so, the study found novel insights into how stem cells work which could help answer questions in regenerative medicine. In the study, the researchers at the University of Zurich and ETH Zurich used single-cell RNA sequencing to investigate cells present in dental pulp and the periodontium. The researchers compared patterns of … Read more