Ozone nano-bubble water is a new antiseptic agent that may potentially be used to treat periodontitis or severe gum infections. Researchers at the Tokyo Medical and Dental University published their research in the journal Science and Technology of Advanced Materials. The researchers evaluated the bactericidal activities of ozone nano-bubble water (known as NBW3) against two bacterial agents that cause periodontitis.
The research results showed that NBW3 can kill periodontal pathogens within 30 seconds of exposure with only a minor impact on the viability of oral tissue cells after 24 hours of exposure. Based on the in vitro results, the researchers concluded that NBW3 could become a potential way to treat periodontitis. Even so in vitro models can not be used directly to compare clinical situations
When treating periodontitis (which is inflammation of oral tissues that surround and support teeth) the first step involves mechanical debridement (scraping away of dental plaque and dental calculus). Different antiseptics and antibiotics have been used to supplement mechanical debridement. Antibiotic therapies have drawbacks such as the selectivity of antimicrobial action, risk for adverse host reactions, and possible development of resistant bacteria.
A possible alternative is ozone which has strong antimicrobial activity against fungi, bacteria, protozoa, and viruses. Aqueous ozone is biocompatible with oral tissue cells. Even so, ozonated water must be used within the first 5 to 10 minutes after production to assure its potency.
The researchers have developed a patented procedure to produce ozone nano bubble water. It is possible for NBW3 to retain its oxidation ability for more than six months if it is protected from exposure to ultraviolet rays. Its high stability allows for the bottling and use of NBW3 as a disinfectant solution. More research needs to be done to see if ozone nano-bubble water (NBW3) can be an effective treatment for periodontitis.
Source: Sae Hayakumo and et al. Effects of ozone nano-bubble water on periodontopathic bacteria and oral cells -in vitrostudies. Science and Technology of Advanced Materials. 2014. 15 (5).
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