Man with infected wisdom tooth dies several weeks later

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In early 2021, a man 44 years of age living in Auckland in New Zealand, died a few weeks after being aware of having an infected wisdom tooth. He first complained of having pain in his lower right wisdom tooth on Christmas Eve in 2020. He went to see a doctor about it several times over many days for swelling and pain and was given antibiotics. He was unable to swallow the pills so was given liquid antibiotics instead but nothing seemed to help with the infection. Later the pain and swelling in his face and neck became progressively worse. He went to the hospital on January 4, 2021. While in the hospital he had x-rays taken and was later discharged. The family was shocked to hear that the man was able to get discharged that soon. He was sent … Read more

Periodontal Disease associated with heart attacks

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In the past on this site links between periodontal disease and cardiovascular disease have been mentioned, see for example the posts Additional link between cardiovascular and periodontal disease and Periodontal Disease and Cardiovascular Risk. Periodontal disease is also known as gum disease. Recently, a study appearing in the Journal of the American Dental Association titled “Association between periodontal care and hospitalization with acute myocardial infarction” written by Romesh P. Nalliah and et. al. (April 19, 2022) has shown that those with periodontal disease are at increased risk of ending up in the hospital due to a heart attack. In the study researchers explored periodontal care and heart attack-related hospitalizations and aftercare by analyzing Iinsurance claims data from MarketScan Research Databases, which includes information from hundreds of millions of patients in the U.S. Patients were included if they had been hospitalized in … Read more

Surgery Free Wisdom Tooth Bud Ablation Treatment To One Day Replace Surgery?

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An interesting article titled “Fully Guided Tooth Bud Ablation in Pigs Results in Complete Tooth Bud Removal and Molar Agenesis” appears in the Journal of Oral and Maxillofacial Surgery written by Leigh E. Colby and David P. Watson, Vol. 81, Issue 4, pp. 456-466, Apr. 2023, Published Dec. 16, 2022. The article seems to be a follow-up to a prior article discussed on this site in the post “Tooth bud abalation of wisdom teeth may be alternative to surgery in the future“. That study had shown that fully guided microwave tooth bud ablation (3TBA) could be used to successfully remove wisdom tooth tooth buds without damaging surrounding tissues in a study with 5 pigs. The most recent study used a 28-day longitudinal characterization study to determine if healing response following fully guided microwave ablation of tooth buds in pigs would result in … Read more

Reducing Anxiety in Wisdom Teeth Surgery using Diazepam and Buspirone

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An interesting article titled “Comparative Evaluation of Efficacy of Oral Diazepam and Buspirone in Reducing Anxiety and Discomfort in Mandibular Third Molar Surgery- In Vivo Study,” by Mitra et al. appears in the Indian Journal of Public Health Research & Development (vol.10, no. 3, Mar. 2019, pp. 182-186). The article seeks to compare the effectiveness of diazepam and buspirone in reducing anxiety and discomfort in lower wisdom teeth removal. The authors were motivated to perform the study because dental anxiety has been reported to range from roughly 4% to 21%. Even more alarming is that up to nearly 50% of patients who have high anxiety have missed a dental appointment at one point. While non medication treatment options exist such as behavioral modification and hypnosis and guided relaxation, some patients may really only respond to medications. Benzodiazepines are the most … Read more

Periodontal Disease Bacteria Tied to Alzheimer’s Disease

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An interesting article titled “Alzheimer’s Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains” appears in the Journal of Alzheimer’s Disease written by Ursula Haditsch et al. (no. 75, pp. 1361–1376, 2020). The article seeks to explore the connections between Porphyromonas gingivalis (P. gingivalis), the main pathogen that causes chronic periodontitis, and Alzheimer’s disease (AD). In the article, the researchers sought to show that intraneuronal P. gingivalis and gingipain expression in vitro after infecting neurons derived from human induced pluripotent stem cells (iPSC). The researchers looked at the effect of the bacteria on the neurons at 24, 48, and 72 hours. The researchers used transmission electron microscopy, confocal microscopy, and bacterial colony to cause infection. They monitored gingipain expression by immunofluorescence and RT-qPCR, and protease activity with activity-based probes. The researchers used immunofluorescence, western blot, and ELISA to … Read more