Topamax Increases Risk of Kidney Stones
Topiramate (Topamax), a drug commonly prescribed to treat seizures and migraine headaches, can increase the propensity of calcium phosphate kidney stones, researchers at UT Southwestern Medical Center have found. A study — the largest cross-sectional examination of how the long-term use of topiramate affects kidney-stone formation — appears in the October issue of the American Journal of Kidney Diseases. Several case reports have described an association between topiramate and the development of kidney stones, but this complication had not been well recognized and physicians have not informed patients about the risk, the UT Southwestern researchers said. More important, the mechanism of stone formation was largely unknown previously. “The wide-spread and escalating use of topiramate emphasizes the importance of considering the long-term impact of this drug on kidney-stone formation,” said Dr. Khashayar Sakhaee, senior author of the study and chief of … Read more